Longitudinal changes in vitamin D during twin pregnancy: association with maternal-neonatal outcomes.

ABSTRACT:

Introduction

Existing studies suggest vitamin D (VD) deficiency links to adverse pregnancy outcomes in singletons; however, its association with specific adverse outcomes and neonatal health in twin pregnancies remains unclear. This study aimed to explore the relationship between maternal VD levels and maternal and neonatal outcomes in twin pregnancies.

Methods

This study collected VD levels, pregnancy conditions, and neonatal anthropometry from 324 twin pregnancies. Peripheral blood serum was collected from mothers in mid- and late pregnancy to measure VD concentrations. Logistic models assessed VD's association with pregnancy complications and neonatal anthropometry. The restricted cubic splines (RCS) method was used to estimate the risk threshold for spontaneous preterm b

SUBMITTER: Dai Z 

PROVIDER: S-EPMC12665537 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature