Gamma knife radiosurgery for cerebral cavernous malformations: biologically effective dose predicts therapeutic outcomes.

ABSTRACT:

Background

Gamma knife radiosurgery (GKRS) is an established option for cerebral cavernous malformations (CCMs) when microsurgical resection is not feasible. Lesion location strongly influences treatment strategy. The biologically effective dose (BED), introduced by J. F. Fowler, has been widely discussed in radiobiology but not evaluated in CCMs.

Methods

A retrospective cohort study was conducted on 107 patients with 123 CCMs treated by GKRS at West China Hospital between June 2020 and December 2022. Post-GKRS hemorrhage was defined as symptomatic bleeding. The annual hemorrhage rate (AHR) quantified bleeding risk, and effective volumetric control was defined as ≥ 20% volume reduction. Clinical outcomes were categorized as improved, stable or worsened.

Results

The me

SUBMITTER: Shi X 

PROVIDER: S-EPMC12665552 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature