Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer.

ABSTRACT:

Background

Dysregulated tumour metabolism is increasingly recognised as a central driver of malignant phenotypes. Against this background, the aberrant metabolism of N-acetylneuraminic acid (Neu5Ac), a core constituent of the sialic acid family, and its impact on breast cancer progression is now receiving significant research attention.

Methods

The purpose of this study is to employ metabolomic approaches to analyze and interpret differences in metabolite profiles connected to breast cancer. Following this, a comprehensive multi-omics analysis will be employed to reveal the differences at transcriptional and metabolic levels in cells after the addition of external sialic acid. Finally, modification proteomics will be applied to recognize and characterize proteins that have d

SUBMITTER: Yang L 

PROVIDER: S-EPMC12665555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature