CHN1 as a potential predictive genetic biomarker for atopic dermatitis-related depression.

ABSTRACT:

Introduction

The comorbidity of atopic dermatitis (AD) and depression has garnered increased attention in recent years, yet the immunopathological mechanisms underlying this connection remain unclear. To bridge this gap, the study aimed to uncover the immune regulatory networks and identify key genetic markers involved in the comorbidity of depression in AD.

Methods

We performed RNA sequencing on peripheral blood mononuclear cells (PBMCs) collected from 20 AD patients with and without depression. By integrating bioinformatics analyses with machine learning, we conducted weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, and employed machine learning models of least absolute shrinkage and selection operator (LASSO) and support vector machine

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12665567 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature