Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.

ABSTRACT:

Background

Diabetes mellitus (DM) has emerged as a rapidly growing global health problem, imposing substantial socioeconomic burdens and multidimensional health consequences, including adverse effects on male fertility. Although accumulating evidence suggests associations between DM and male reproductive dysfunction, comprehensive mechanistic insights, particularly through inflammatory pathways, remain inadequately elucidated.

Method

We conducted a systematic literature search on Web of Science, Embase, and PubMed databases (1972-2022) to investigate DM-related male infertility through meta-analysis. Following PRISMA guidelines, eight of 168 studies on type 1 diabetes (T1D) and nine of 185 studies on type 2 diabetes (T2D) were included to screen the relationship between diab

SUBMITTER: Hao Y 

PROVIDER: S-EPMC12665571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature