Coronary heart disease and type 2 diabetes metabolomic signatures in the Middle East.

ABSTRACT:

Background

The growing field of metabolomics has opened new venues for identifying biomarkers of type 2 diabetes (T2D) and predicting its consequences, such as coronary heart disease (CHD). Despite their large size, Middle Eastern populations are underrepresented in omics research. In this study, we aim at investigating metabolomics profiles of T2D stratified by the CHD comorbidity for Middle Eastern population, such as Qatari population.

Methods

In this cross-sectional study, we used a total of 641 metabolites from a large cohort of 3,679 Qatari adults from the Qatar BioBank (QBB; 272 T2D and 2,438 non-T2D individuals) and Qatar Cardiovascular Biorepository (QCBio; all CHD patients; 488 T2D and 481 non-T2D individuals). Univariate and pathway enrichment analyses were perfor

SUBMITTER: Elshrif M 

PROVIDER: S-EPMC12665572 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature