Effect of bardoxolone methyl on the lower reproductive tract microbiome in turkey breeder hens.

ABSTRACT:

Introduction

Fertility decline in aging turkey breeder hens is associated with reduced sperm storage in the uterovaginal junction (UVJ), inflammation, oxidative stress, and tissue aging. The mucosal microbiome is an important contributor to subfertility, with shifts in immune function, inflammation, and oxidative stress linked to microbial changes. Bardoxolone methyl, a potent activator of the nuclear erythroid 2-related factor 2 (NRF2) pathway, enhances antioxidant defenses and reduces inflammation. This study investigated if bardoxolone methyl treatment alters the microbial composition and diversity of the UVJ and vagina in turkey hens.

Methods

Forty turkey hens (59 weeks old) were randomly assigned to a bardoxolone methyl group (n = 20) or a control group (n = 20). Birds

SUBMITTER: Nabthonglang J 

PROVIDER: S-EPMC12665593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature