A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis.

ABSTRACT:

Purpose

Gastric signet ring cell carcinoma (GSRC) is a distinct gastric cancer (GC) subtype. This study aimed to develop and validate a nomogram to predict overall survival (OS) and guide clinical decision-making.

Methods

This study included 2,203 GSRC patients from the SEER database (2010-2019), randomly split into a modeling cohort (n = 1,542) and an internal validation cohort (n = 661). An external cohort of 74 patients from the Second Affiliated Hospital of Nanjing Medical University (2019-2024; median follow-up 34 months) was used for validation. Predictor variables-age, sex, chemotherapy, lymph node ratio (LNR), T and M categories, tumor size, and tumor number-were included in a cox proportional hazard model. A nomogram was derived from the cox model and internally val

SUBMITTER: Wu J 

PROVIDER: S-EPMC12665595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature