High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice.

ABSTRACT:

Background

Obesity is associated with cognitive function impairment. We previously found that male, but not female, mice have poorer performance in learning and memory tasks and impaired hippocampal synaptic plasticity after long-term high-fat diet (HFD) consumption, compared to regular chow-fed counterparts. To elucidate the potential morphological mechanism(s), here we further performed morphometric analysis of hippocampal dendritic morphology and complexity in HFD and control groups of both sexes.

Methods

C57BL/6 J mice with both sexes were fed HFD (45% kcal% fat) after weaning for 12 months. Age-matched control mice were fed regular chows (13.5 kcal% fat). Morphometric analysis of Golgi-stained dendrites in hippocampal slices was performed to compare the dendritic morpho

SUBMITTER: Teng SF 

PROVIDER: S-EPMC12665603 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature