Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient Pooled Analysis of Four Randomized Controlled Trials.

ABSTRACT:

Purpose

This study assessed intravenous thrombolysis (IVT) prior to endovascular treatment (EVT) versus EVT alone in patients with basilar artery occlusions (BAO).

Methods

This patient-level pooled analysis included data from four randomized controlled trials within the VERITAS collaboration (BEST, BASICS, ATTENTION, and BAOCHE). Patients were stratified into IVT plus EVT and EVT alone. Primary outcome was favorable functional outcome, defined as modified Rankin Scale (mRS) score of 0-3 at 3 months. Secondary outcomes included good functional outcome (mRS 0-2), mortality, and symptomatic intracranial hemorrhage (sICH) rates. Regression analyses were adjusted for covariates identified from baseline differences and univariable analyses. Inverse probability of treatment weighti

SUBMITTER: Knapen RRMM 

PROVIDER: S-EPMC12665628 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature