Mucinous cystic neoplasms of the pancreas demonstrate <i>in situ</i> production of estrogen.

ABSTRACT:

Introduction

Mucinous cystic neoplasms (MCNs) are rare cystic tumors that may occur in the liver, pancreas, or retroperitoneum, defined histologically by the presence of an "ovarian type stroma." While this morphology has been well characterized, it remains unknown whether the tumor stroma is functionally active. In our current study, we describe the detection of estrogen and its metabolites in the ovarian-type stroma of MCN tumors of the pancreas.

Methods

Using a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique. We performed LC-MS/MS on 14 cases of MCN, with and without dysplasia, following macro dissection from formalin fixed tissue.

Results

We identified that relative to histologically normal pancreas, and intraductal papillary mucinous neo

SUBMITTER: Kim J 

PROVIDER: S-EPMC12665673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature