Host angiogenic reprogramming by <i>Echinococcus multilocularis</i> protoscoleces protein via PDGFR/PI3K/AKT cascade.

ABSTRACT:

Background

Alveolar echinococcosis (AE) is a globally present zoonotic disease caused by Echinococcus multilocularis (E. multilocularis) infection, characterized by the formation of tumor-like growths primarily in the liver, with the potential to spread to other organs. Similar to tumors, E. multilocularis infection is accompanied by pathological angiogenesis, suggesting that the implementation of anti-angiogenic therapeutic strategies may also have promising applications in the treatment of AE. However, the mechanism of angiogenesis in AE remains unclear and has not been fully elucidated.

Results

In this study, we discovered that angiogenesis related genes are significantly up-regulated in the mouse model of E. multilocularis infection and pathol

SUBMITTER: Bi X 

PROVIDER: S-EPMC12665720 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature