Mercury exposure, epigenetic modifications, and genetic susceptibility: insights from molecular docking and population analysis.

ABSTRACT:

Introduction

Mercury (Hg) is a major environmental contaminant and public health concern, particularly in industrial regions where metallurgical activities contribute to elevated Hg emissions. Genetic factors influencing susceptibility to mercury toxicity remain underexplored in Central Asia. This study investigated genetic predisposition to Hg accumulation and toxicity among residents of Temirtau, Kazakhstan.

Methods

A total of 180 residents from Temirtau and 90 control participants were enrolled. Mercury concentrations were measured in blood and hair samples using cold vapor atomic absorption spectrometry. Dietary information was collected to identify major exposure routes. Genotyping for GSTM1, GSTT1, GSTP1 (Ile105Val, rs1695), and GCLM (-588C/T, rs41303970) polymorphisms

SUBMITTER: Serik B 

PROVIDER: S-EPMC12665739 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature