<i>Akkermansia muciniphila</i> and its culture supernatant ameliorate colitis in interleukin-10 knockout mice via gut barrier and immune modulation.

ABSTRACT:

Background

Akkermansia muciniphila (A. muciniphila) is a mucin-degrading commensal bacterium with established roles in maintaining intestinal homeostasis and modulating host immune responses. However, its therapeutic potential and mechanisms in chronic spontaneous colitis remain incompletely defined. Interleukin-10 knockout (IL-10^-/^-) mice are a well-established model of spontaneous colitis due to impaired anti-inflammatory cytokine signaling and disrupted immune regulation. In this study, we aimed to determine whether A. muciniphila and its culture-derived supernatant could ameliorate intestinal inflammation in IL-10^-/^- mice.

Methods

We administered A. muciniphila or its culture supernatant (A. mucin

SUBMITTER: Jiang M 

PROVIDER: S-EPMC12665751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature