Optimizing pediatric AKI diagnosis: a patient-tailored meta-analysis of urinary TIMP-2/IGFBP7 performance across clinical scenarios and assay platforms.

ABSTRACT:

Objective

To systematically evaluate the diagnostic value of urinary cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), for the early diagnosis of acute kidney injury (AKI) in children using a meta-analysis.

Methods

Nine databases were searched (inception-May 2025). Two reviewers independently screened studies, extracted data, and assessed quality (QUADAS-2). Bivariate models (STATA 18.0) generated pooled estimates.

Results

15studies (1,338participants; 337 AKI cases) were included. Overall accuracy: Sensitivity 0.84 (95% CI: 0.71-0.91), Specificity 0.85 (95% CI: 0.76-0.91), AUROC 0.91. Key subgroups: High-risk Neonates: AUROC 0.96, NLR 0.13 (95% CI: 0.02-0.78), Critically Ill/Seps

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12665772 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature