Comparison of sarcopenia prevalence and prognostic features between HFrEF and HFpEF: a systematic review and meta-analysis.

ABSTRACT:

Background

Sarcopenia is closely associated with heart failure (HF); however, no prior meta-analysis has specifically addressed its relation with different ejection fraction phenotypes. This study investigated the prevalence of sarcopenia in patients with HF with reduced ejection fraction (HFrEF) vs. those with preserved ejection fraction (HFpEF), compared their prevalence rates, and explored the prognostic outcomes associated with sarcopenia in these phenotypes.

Methods

PubMed, Cochrane, and Embase databases were searched from their inception to February 2025. Studies reporting the prevalence or prognosis of sarcopenia in patients with HF and defined ejection fraction phenotypes were included. Two authors independently assessed study quality using the Newcastle-Ottawa Scale

SUBMITTER: Xiong W 

PROVIDER: S-EPMC12665785 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature