Association Between Insulin Therapy and In-Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume.

ABSTRACT:

Aims

To examine the association of insulin therapy with in-hospital death and whether this association is mediated by elevated plasma volume among chronic heart failure (CHF) patients with type 2 diabetes mellitus (T2DM).

Materials and methods

A retrospective study combining two electronic medical records: the Medical Information Mart for Intensive Care (MIMIC) database and the Tianjin Heart Failure with Integrated Treatment (TJHFIT) database. Propensity score matching (1:2 ratio) was conducted in CHF-T2DM patients to eliminate the differences in demographics, comorbidity, and the severity of diabetes. Then, conditional logistic regression, restricted cubic spline (RCS) modeling, and mediation analysis were processed.

Results

A total of 7997 CHF-T2DM patients were inc

SUBMITTER: Luo X 

PROVIDER: S-EPMC12665801 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature