Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Lepr^em1hwl/Korl and C57BLKS/J-Lepr^db/J mice.

ABSTRACT: The Lepr gene encodes a receptor for leptin, a hormone instrumental in the regulation of appetite and metabolism. Mutations in the Lepr gene impair leptin signaling, leading to metabolic dysfunctions and facilitating the development of non-alcoholic fatty liver disease (NAFLD). In this study, we compared the NAFLD-associated phenotypes of two mutant strains of mice, C57BL/6J-Lepr^em1hwl/Korl (Lepr^em1hwl) and C57BLKS/J-Lepr^db/J (Lepr^db/db), carrying different alleles of the Lepr gene. Although both Lepr^em1hwl and Lepr^db/db mice were characterized by similar obesity phenotypes, leptin resistance, insulin resistance, and glucose intolerance, comparatively, Lepr^em1hwl mice were found to have relatively more severe hepa

SUBMITTER: Lee S 

PROVIDER: S-EPMC12665989 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature