Next-Generation Percutaneous Catheter-Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies.

ABSTRACT: Safe and efficient in vivo delivery of advanced therapies (ATs) remains a major challenge hindering their path to clinical adoption. We present a novel, fully percutaneous, catheter-based locoregional perfusion (LRP) system for targeted delivery of ATs, minimizing systemic exposure. Using principles from extracorporeal membrane oxygenation and cardiovascular perfusion, we developed and validated the LRP concept in porcine models, focusing on the kidney as a clinically relevant target. Custom catheter prototypes enabled safe, isolated perfusion of the kidney. Using adeno-associated viruses (AAVs) as model cargos, LRP achieved up to 69,000-fold higher vector retention within the LRP circulation than systemic circulation, and significantly reduced delivery to off-target organs such as the liv

SUBMITTER: Emmert MY 

PROVIDER: S-EPMC12666019 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature