Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts.

ABSTRACT: Bikunin is a proteoglycan with a core protein and a low sulfated chondroitin 4-sulfate (Ch4S) chain. This chain has low 4-sulfated glucuronic acid-N-acetylgalactosamine (GlcUAβ1-3GalNAcβ1-4) repeating disaccharide units, and is covalently linked to the core protein through a glucuronic acid-galactose-galactose-xylose-serine the linkage tetrasaccharide (GlcUAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser¹⁰). The linkage tetrasaccharide is sometimes complexly modified by phosphorylation on Xyl, sulfation on Gal, fucosylation on Xyl, or sialylation on Gal, or combinations of them. Bikunin is used in obstetrics to prevent preterm birth caused by bacterial infection inflammation in Japan. However, the role of the Ch4S chain in the anti-inflammatory action of bikunin has not been fully c

SUBMITTER: Kurotaki S 

PROVIDER: S-EPMC12666056 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature