BMDB: An integrated database and web platform for single-cell transcriptomic profiling of bone marrow microenvironment.

ABSTRACT: The bone marrow microenvironment orchestrates hematopoiesis and disease processes, yet its profound cellular and molecular complexity remains incompletely resolved. While single-cell RNA sequencing offers unprecedented resolution, the lack of a unified resource integrating niche-specific data across health and disease states, and developmental stages hinders systematic exploration. Here, we present BMDB (https://bmdb.jflab.ac.cn:8084/), an integrated database and web platform aggregating 435,682 single cells from 142 healthy and 82 pathological human and mouse samples, establishing species- and stage-specific reference atlases that harmonize niche cell annotation, improve cross-study comparability, and enable translational analyses. Its interactive web platform provides modules for functio

SUBMITTER: Chen J 

PROVIDER: S-EPMC12666060 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature