Cell-type specific single-cell signatures reveal nephrotoxic drug effects.

ABSTRACT: Drug-induced acute kidney injury (AKI) affects about 20 % of hospitalized AKI patients, a significant contributor to morbidity and mortality. The lack of understanding of the kidney system and functioning of nephrotoxic drugs contributes to hospital-acquired AKI cases. AKI is difficult to predict because of its complex injury mechanism and the numerous pathways through which it manifests. Traditional toxicity biomarkers, like elevated creatinine levels, detect AKI only after significant kidney injury has occurred. Concurrently, advancements in single cell RNA sequencing (scRNAseq) have improved our ability to map cellular heterogeneity within tissues, potentially enabling the study of drug effects at a single cell level. We hypothesized that only particular subtypes of kidney cells may be

SUBMITTER: Kuchi A 

PROVIDER: S-EPMC12666064 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature