Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT.

ABSTRACT:

Objective

To investigate complement system activation and complement protein levels in relation to radiographic progression in axial spondyloarthritis (axSpA) within a longitudinal randomised controlled trial (RCT) of radiographic axSpA patients initiating tumour necrosis factor inhibitor (TNFi) therapy.

Methods

Serum samples from 96 patients with active radiographic axSpA in the multicentre RCT CONSUL were analysed by immunoassays for complement activation, that is, C3dg and complement proteins (MBL, CL-L1, M-, H- and L-ficolin; MASP-1,-2 and -3; and MAp44) before and after 108 weeks of TNF inhibitor therapy with golimumab.

Results

Baseline serum levels of total complement activation, that is, C3dg and lectin pathway activating protease MASP-1 were elevated in patien

SUBMITTER: Mistegaard C 

PROVIDER: S-EPMC12666074 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature