Association between periprocedural change in serum renalase and microvascular obstruction in patients with STEMI after primary percutaneous coronary intervention: protocol for the ReMVOS prospective cohort study.

ABSTRACT:

Introduction

Microvascular obstruction (MVO) is a common complication following primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) and is strongly associated with adverse clinical outcomes. MVO is a dynamic, multifactorial process shaped by factors spanning the myocardial infarction-reperfusion continuum and by PPCI-related microcirculatory injury, which leaves current early risk stratification-often a static snapshot-with limited power to anticipate its evolution. Renalase, a cardioprotective enzyme, exhibits a post-reperfusion surge that parallels MVO development; periprocedural renalase release may likewise be driven by overlapping mechanisms along the ischaemia-reperfusion pathway. This hypothesis-generating observation supp

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12666095 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature