Dual functional properties of a probiotic biofilm-decorated bone substitute to combat infection and promote osteoimmunomodulation.

ABSTRACT: Oral and maxillofacial bone defects are prevalent and challenging to treat, often leading to significant complications such as infection and impaired healing. Enhancing the antibacterial and osteoimmunomodulatory properties of bone graft materials represents a promising approach to improve regenerative outcomes. In this study, we developed a hydroxyapatite scaffold coated with a biofilm of the probiotic Akkermansia muciniphila (Akk-HA), engineered to simultaneously combat infection and modulate the immune environment. Akk-HA exhibited vigorous anti-adhesive activity against pathogenic bacteria and attenuated inflammatory responses by suppressing proinflammatory cytokine secretion while promoting the release of proregenerative mediators from macrophages. Mechanistic stu

SUBMITTER: Song S 

PROVIDER: S-EPMC12666132 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature