Alectinib as salvage therapy for metastatic UIMT following misdiagnosis: A case enabling definitive surgery and prolonged remission.

ABSTRACT:

Background

Uterine inflammatory myofibroblastic tumor (UIMT) is a rare, aggressive tumor often mistaken for uterine fibroids. This case report discusses managing advanced UIMT after a misdiagnosis and assesses the effectiveness of the anaplastic lymphoma kinase (ALK) inhibitor, alectinib, as a targeted treatment.Case presentationA 29-year-old woman had a laparoscopic myomectomy for presumed uterine fibroids. Three months later, she developed abdominal distension, vaginal bleeding, and fever. Pathological evaluation confirmed a diagnosis of UIMT with aggressive behavior, and imaging showed extensive abdominal metastases. She received supportive therapies including hepatoprotection, infection control, and hemostasis. Due to the substantial tumor burden and malnutrition, targeted ther

SUBMITTER: Shuang T 

PROVIDER: S-EPMC12666138 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature