Cardiac substructure radiotherapy dose and changes in physical activity and quality of life after chemoradiotherapy for NSCLC: a secondary analysis of the CLARITY prospective study.

ABSTRACT:

Purpose

The objective was to assess associations between cardiac substructure dose and changes in patient-reported outcomes (PROs) post-chemoradiotherapy for non-small cell lung cancer (NSCLC).

Methods and materials

The study population was derived from CLARITY (NCT04305613), a multi-institutional longitudinal prospective cohort study. Patients treated with conventionally fractionated radiotherapy (1.8-2 Gy per fraction) with concurrent chemotherapy completed physical activity (Godin) and quality of life (FACIT-Fatigue and Dyspnea) questionnaires at baseline, completion of radiotherapy, 6 and 12 months post-radiotherapy. Thirty cardiac dosimetric parameters were a priori selected from centrally contoured radiotherapy plans: mean dose, maximum dose, volume receiving ≥ 

SUBMITTER: Yegya-Raman N 

PROVIDER: S-EPMC12666144 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature