FXR-mediated antigen-specific CD8⁺ T cell enhances antitumor immunity in intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Intrahepatic cholangiocarcinoma (ICC) offers limited opportunities for surgical treatment, and advanced-stage patients exhibit poor responses to immunotherapy. Therefore, the exploration of new therapeutic strategies is of paramount importance. The farnesoid X receptor (FXR) is a nuclear receptor that has been reported to regulate immune cells in recent years. However, whether FXR can regulate CD8⁺ T cells to affect tumor development remains unknown.

Methods

The function of FXR in CD8⁺ T cell-mediated antitumor immunity was assessed using spontaneous murine ICC models in systemic Nr1h4-knockout, and T cell-specific conditional knockout mice, with immune phenotyping performed by multicolor flow cytometry. The tumor antigen-specific CD8<

SUBMITTER: Liu S 

PROVIDER: S-EPMC12666157 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature