Association between exposure to proton pump inhibitors and hypertension: a descriptive and disproportionality analysis of VigiBase.

ABSTRACT:

Objectives

The potential link between proton pump inhibitors (PPIs) and hypertension remains unclear. It is uncertain whether such an association exists, whether it represents a class-of-PPI effect and whether a dose-response relationship is involved. This study aimed to investigate the potential class-of-PPI effect associating PPIs with hypertension reporting and evaluate whether the association follows a dose-dependent pattern.

Design

A disproportionality analysis was conducted within VigiBase to identify signals of hypertension reporting associated with individual PPIs by calculating adjusted reporting ORs (aRORs) within a multivariate case/non-case study design. Additionally, the presence of a dose-response relationship was explored.

Setting

Real-world data from V

SUBMITTER: Chretien B 

PROVIDER: S-EPMC12666159 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature