Cervical intraepithelial neoplasia progression and regression among women living with HIV in Zambia.

ABSTRACT:

Objectives

Cervical screening and precancer treatment are less effective in women living with HIV (WLWH) than in women without HIV. We assessed high-risk human papillomavirus (HR-HPV) infection and cervical disease progression among screened WLWH in Zambia.

Methods

Participants underwent visual inspection with acetic acid (VIA), HR-HPV testing and cervical biopsies at baseline and at follow-up 30-36 months later. Women with positive VIA results or high-grade histology were offered treatment. We assessed HR-HPV and cervical disease prevalence at both timepoints and used multivariable logistic regression to identify factors associated with cervical disease progression and regression.

Results

Among 241 included women, HR-HPV prevalence declined from 44% (95% confidence i

SUBMITTER: Andoh J 

PROVIDER: S-EPMC12666240 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature