Genetic landscape of morphine response in BXD recombinant inbred mice.

ABSTRACT: Morphine is a potent analgesic and exhibits significant efficacy in alleviating severe pain. However, prolonged use can lead to drug dependency. Moreover, there are individual variations in response to and tolerance of morphine, indicating potential genetic regulation. Nevertheless, the mechanisms underlying these phenomena remain unclear. Therefore, we aimed to systematically dissect the genetic regulatory network for morphine response. We used quantitative trait locus mapping to identify genetic regions associated with morphine-related traits. Candidate genes for each locus were further filtered based on multiple criteria, including gene-trait association, cis-regulation, genetic variation, and potential function. The results showed that morphine response-related behavioral traits were s

SUBMITTER: Yin Q 

PROVIDER: S-EPMC12666343 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature