Mapping the oxidative stress metabolome in neurology by gas chromatography-mass spectrometry: a systematic review on signature-driven diagnosis and disease monitoring.

ABSTRACT: Oxidative stress is a pivotal factor in the pathogenesis of neurological conditions; however, its clinical assessment is constrained by the ephemeral nature of reactive species and the variability of analytical methodologies. Gas chromatography coupled with mass spectrometry (GC-MS) provides high sensitivity, molecular specificity, and well-established libraries, positioning it as a promising translational platform for the mapping of oxidative-stress-related metabolites in neurological disorders. We conducted a PRISMA-guided, PROSPERO-registered systematic review of human studies employing GC-MS to quantify oxidative-stress-linked metabolites in central nervous system disorders (January 2014-January 2025). Two independent reviewers screened records from PubMed and Scopus, extracted study a

SUBMITTER: Lorca C 

PROVIDER: S-EPMC12666437 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature