Oral diseases as emerging risk factors for Alzheimer's disease: A scoping review.

ABSTRACT: This scoping review examined current evidence on the relationship between oral diseases and Alzheimer's disease (AD). Systematic searches were conducted in PubMed, Scopus, Web of Science, Google Scholar, and KMbase for studies published from 1990 to December 2024, using terms of Alzheimer's disease, dementia, oral health, periodontal disease, dental caries, and tooth loss. Human and validated animal studies investigating microbiological, immunological, inflammatory, genetic, or functional links between oral health and AD were included. Of 1328 records, 841 remained after duplicates were removed, and 98 were reviewed in full; 45 met inclusion criteria. Findings were organized into four themes: general associations; periodontal disease and AD, including inflammation, amyloid-β pathways, and

SUBMITTER: Yi Y 

PROVIDER: S-EPMC12666449 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature