The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings.

ABSTRACT: Skeletal muscle injury and repair have been a major research focus for more than a century. Muscle injuries are defined by their cause and anatomical location and lie on a spectrum in terms of repair outcomes. From contraction-induced necrosis, which initiates regenerative myogenesis for complete restoration of tissue architecture and function to, at the other end of the spectrum, traumatic volumetric muscle loss (VML), where substantial portions (or the whole) of a muscle are lost, leaving the patient with permanent physical disability. Strain injuries are found between these two extremes and are characterised by healing with scar tissue formation and a high re-rupture rate. Across these injury types, a discriminating feature for a successful outcome is the preservation of the extracellul

SUBMITTER: Hojfeldt G 

PROVIDER: S-EPMC12666502 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature