Comprehensive assessment of endothelial dysfunction before cellular therapy: EASIX, local imaging, and systemic biomarkers.

ABSTRACT: Endothelial dysfunction contributes to mortality after cellular therapies, yet its clinical assessment remains challenging. In this prospective observational study, we evaluated 169 patients undergoing allogeneic stem cell transplantation or chimeric antigen receptor T-cell therapy and 102 healthy controls to determine whether a comprehensive endothelial profile, including the endothelial activation and stress index (EASIX), glycocalyx thickness (via sublingual GlycoCheck microscopy), digital perfusion (Tivita hyperspectral imaging), endothelial serum markers (angiopoietin-2, soluble thrombomodulin [CD141], chemokine (C-X-C motif) ligand 8, chemokine (C-X-C motif) ligand 9, interleukin-18, enzyme-linked immunosorbent assays), and platelet aggregation (flow cytometry), correlates with clini

SUBMITTER: Simons L 

PROVIDER: S-EPMC12666521 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature