Failure-to-rescue as a determinant of overall survival following resection for perihilar cholangiocarcinoma.

ABSTRACT:

Background & aims

Perihilar cholangiocarcinoma (pCCA) is a surgically challenging malignancy associated with a high risk of postoperative complications. However, advances in surgical techniques, perioperative care, and systemic therapy might have improved overall survival (OS) over time. This study investigated the evolving impact of failure-to-rescue (FTR) rates and oncological treatment strategies on outcomes in patients with pCCA after curative surgery.

Methods

Patients undergoing curative-intent resection for pCCA at the Mayo Clinic between 2000 and 2024 were retrospectively reviewed. Clinicopathological features were compared across three surgical eras. OS and recurrence-free survival (RFS) were assessed using Kaplan-Meier analysis, with direct matching applied to accou

SUBMITTER: Dong Y 

PROVIDER: S-EPMC12666550 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature