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ABSTRACT: Background
Health information systems (HIS) are critical for digital health transformation, yet fragmentation and poor interoperability adoption remains a major challenge.Objectives
This study systematically reviews architectural patterns used in HIS and evaluates their alignment with ecosystem-level requirements.Methods
Following PRISMA 2020 guidelines, a systematic literature review was conducted across Scopus, IEEE Xplore, PubMed, and Web of Science (2020-2025). Eligible studies described, evaluated, or proposed HIS solutions.Results
From an initial set of 304 records, 89 met the inclusion criteria. Service-based and decentralized/distributed ledger architectures were predominant, with emerging models integrating edge computing and modular design. FHIR-ba
SUBMITTER: Casanova R
PROVIDER: S-EPMC12666560 | biostudies-literature | 2025
REPOSITORIES: biostudies-literature