Diagnostic accuracy of transient elastography in MASLD is independent of MRI-PDFF steatosis in a multicenter study.

ABSTRACT:

Background

Transient elastography (TE) can be used to accurately screen for severe liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). However, some studies suggest that steatosis influences liver stiffness measurement (LSM). Thus, treatment that modifies steatosis might impact the relevance of TE in the management of patients. The use of magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) has shown good reliability and accuracy for quantifying hepatic steatosis. Therefore, the aim of our study was to evaluate the performance of TE combined with MRI-PDFF for the diagnosis of severe fibrosis in patients with MASLD. The study is registered at ClinicalTrials.gov (NCT03245606).

Methods

In this prospective multicenter study, patient

SUBMITTER: Masrour O 

PROVIDER: S-EPMC12666573 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature