Jugular bulb venous to arterial carbon dioxide gradient is associated with treatment-responsive phenotypes of hypoxic-ischemic brain injury.

ABSTRACT:

Background

The difference between the jugular bulb venous and arterial carbon dioxide (CO₂) tension, the cerebral pCO₂ gap, is a marker of global tissue perfusion and can be affected by various mechanisms that underlie hypoxic-ischemic brain injury (HIBI). We hypothesized the CO₂ gap and SjvO₂ together could identify treatment responsive pathophysiology among those with abnormally elevated SjvO₂.

Methods

In this retrospective study including post-arrest patients, we quantified the relationship between pCO₂ gap and SjvO₂ using hierarchical regression. Among patients with elevated SjvO₂, we assessed whether pCO₂ gap predicted response to treatment with hyperosmolar therapy using

SUBMITTER: Faiver L 

PROVIDER: S-EPMC12666575 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature