Prodrug-loaded micelles targeting articular cavity reactive oxygen species for rheumatoid arthritis treatment.

ABSTRACT: Oxidative stress plays an important role in the pathogenesis of rheumatoid arthritis (RA). Excessive reactive oxygen species (ROS) activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome, release multiple inflammatory mediators, stimulate macrophage polarization, and exacerbate the inflammatory response. In response to the pathological features of RA, we designed a dihydroartemisinin (DHA)-ROS sensitive prodrug loaded into carriers of Soluplus and Vitamin E polyethylene glycol succinate (TPGS) using a thin film hydration to expect that the nano-micelles could target for delivery to the inflammation site due to extravasation through leaky vasculature and subsequent inflammatory cell-mediated sequestration (ELVIS) effects, and the higher ROS level in articular cavity resulting

SUBMITTER: Meng M 

PROVIDER: S-EPMC12666583 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature