Injectable cationic dynamic hydrogel with supramolecular drug loading reprograms neutrophil fate to alleviate diabetic periodontitis.

ABSTRACT: The pervasive infiltration of tissue-destructive yet microbicidal-impaired neutrophil extracellular traps (NETs) constitutes a primary mechanistic driver of diabetic periodontitis refractoriness. Apoptosis facilitates nonphlogistic turnover of neutrophils, but excessive activation leads to the release of an excessive amount of dysfunctional NETs, causing tissue damage in diabetic periodontitis. To co-target pathological NETosis and dysbiotic infection, we engineered an injectable cationic dynamic hydrogel (ICDH) with supramolecular drug loading via grafting phenylboronic acid onto cationic poly-L-lysine, crosslinking with polyvinyl alcohol via dynamic borate esters, and loading immunomodulatory agents (chlorogenic acid and metformin) via supramolecular interactions. This innovative design

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12666585 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature