Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation.

ABSTRACT: The mechanistic link between periodontitis (PD) and rheumatoid arthritis (RA) remains poorly understood. This study aimed to investigate whether PD-associated salivary microbiota exacerbates RA via an "oral-gut-immune axis." We performed 16S rRNA sequencing and untargeted metabolomics on saliva from healthy controls and patients with PD, RA, or both (PD-RA). Salivary microbiota from PD patients or healthy controls were transplanted into collagen-induced arthritis (CIA) mice. Clinically, PD-RA patients exhibited enrichment of periodontal pathogens (e.g., Porphyromonas sp., Prevotella sp.) and pro-inflammatory lipid metabolites. In vivo, transplantation of PD microbiota into CIA mice significantly worsened arthritis, evidenced by higher clinical scores (3.5 ± 0.5 vs. 2.3 ± 0.4, p < 0.05) and

SUBMITTER: Ge R 

PROVIDER: S-EPMC12666613 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature