Liver Fat Quantification and Steatosis Grading in Fatty Liver Disease by Magnetic Resonance Imaging: Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

Magnetic resonance imaging (MRI) surrogate biomarkers are widely utilized to diagnose and monitor metabolic dysfunction-associated steatotic liver disease (MASLD). This meta-analysis assesses their effectiveness in quantifying liver fat and grading steatosis.

Methods and results

Scopus, Web of Science, and MEDLINE (PubMed) were systematically searched up to February 20, 2024. Eligible studies included original research in English, focusing on MRI-based assessments of hepatic steatosis in humans with no comorbidities, with magnetic resonance spectroscopy (MRS) or pathology as the reference standard. Fat fraction and steatosis grade were evaluated using correlation, mean difference, and diagnostic accuracy metrics. This review was registered with PROSPERO with registration

SUBMITTER: Al-Huneidi LI 

PROVIDER: S-EPMC12666615 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature