Long-term body mass index variability and the risk of cardiometabolic multimorbidity in middle-aged and older adults: Insights from two prospective cohorts.

ABSTRACT:

Background

Body mass index (BMI) variability is considered to be associated with an increased risk of various diseases. However, the association between long-term BMI variability and cardiometabolic multimorbidity (CMM) remains elusive, especially in middle-aged and older adults. This study aimed to explore their relationship in two prospective cohorts.

Methods

Data were analyzed from the UK Biobank and the China Health and Retirement Longitudinal Study (CHARLS). CMM was defined as the coexistence of two or three cardiometabolic diseases, including diabetes mellitus, coronary heart disease, and stroke. BMI measurements from three visits were utilized to assess BMI variability. Cox regression analysis was employed to estimate the relationship between BMI variability and CMM.<

SUBMITTER: Ren X 

PROVIDER: S-EPMC12666677 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature