A comprehensive metabolomic dataset of human synovial fluid in osteoarthritis and healthy controls.

ABSTRACT: Osteoarthritis (OA) is a prevalent degenerative joint disorder that causes chronic pain and disability. The synovial fluid (SF), which bathes the joint, reflects the pathological state and is a valuable source for biomarker discovery. However, a comprehensive metabolomic profile of SF in OA remains to be fully established. Here, we present a comprehensive metabolomic dataset derived from SF samples of 10 OA patients and 10 matched healthy controls. Using non-targeted metabolomics based on ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-MS), we identified 23,232 features, with 1431 metabolites annotated. Comparative analysis revealed 163 significantly differential metabolites (118 upregulated, 45 downregulated). Functional enrichment and pa

SUBMITTER: Chen P 

PROVIDER: S-EPMC12666683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature