Novel Molecular Subtyping Predicts Locoregional Recurrence in Triple-negative Breast Cancer.

ABSTRACT:

Purpose

Immunohistochemistry (IHC)-based molecular subtyping provides a comprehensive profile of triple-negative breast cancer (TNBC). We aimed to elucidate patterns of locoregional recurrence (LRR) in different subtypes of TNBC.

Methods and materials

In this study, 352 patients with breast cancer treated with mastectomy and postmastectomy radiation therapy from November 2019 to March 2022 were retrospectively analyzed. Based on IHC, these patients were classified into the basal-like immune-suppressed (BLIS) and non-BLIS groups. We compared LRR as the first event, disease-free survival, and overall survival (OS) between the 2 groups. Univariate and multivariate analysis was performed.

Results

The median follow-up time was 44.6 months. Twenty-six LRR (including 9 isola

SUBMITTER: Shao S 

PROVIDER: S-EPMC12666700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature