MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway.

ABSTRACT:

Background

Esophageal cancer (ESCA) remains difficult to treat with surgery and chemotherapy showing limited impact on patient prognosis. Matrix metalloproteinase 11 (MMP11) has been linked to tumor progression and immune microenvironment modulation. This study explored MMP11's role in regulating the PD-L1/c-Myc pathway in ESCA.

Methods

MMP11 expression was analyzed in ESCA tissues and cell lines using real-time PCR and western blot. Kaplan-Meier survival curves assessed the relationship between MMP11 expression and patient survival. Functional assays, including wound healing and flow cytometry, were conducted to examine ESCA cell migration and apoptosis.

Results

MMP11 silencing reduced PD-L1 expression and inhibited cell migration, while promoting apoptosis. It also

SUBMITTER: Li S 

PROVIDER: S-EPMC12666701 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature