Risk Factors of Cardiotoxicity After Breast Cancer Radiation Therapy.

ABSTRACT:

Purpose

Concern for cardiotoxicity after the treatment of breast cancer necessitates a better understanding of factors that may increase the risk of significant (grade ≥3) cardiac events. We investigated clinical factors, coronary artery calcium (CAC), and radiation therapy dose to cardiac structures as predictive post-radiation therapy cardiotoxicity risk factors.

Methods and materials

We retrospectively analyzed a cohort of serial patients treated with neoadjuvant chemotherapy for stage I to III breast cancer from 2005 through 2014. We measured the incidence of cardiac events after treatment, adjusting for the competing risk of death.

Results

We identified 174 patients with a median follow-up of 117 months and a median age of 47 years. The 10-year incidence of grade

SUBMITTER: Guo FB 

PROVIDER: S-EPMC12666710 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature