Inflammatory Markers Associated With Radiation-Induced Lung Injury, Metastasis and Mortality After Breast Cancer Treatment.

ABSTRACT:

Purpose

Breast cancer (BC) radiation therapy (RT) prevents local recurrence and improves survival. However, it can induce acute and late effects on organs at risk, such as the lung. In some patients, radiation activates inflammatory markers, which promote inflammation in the lung leading to radiation pneumonitis and fibrosis (RF). Moreover, inflammatory markers may be associated with metastatic disease and survival. This study examines the relationships between inflammatory markers and clinical radiation pneumonitis and RF and explores their potential to predict BC metastasis or overall survival.

Methods and materials

Patients prescribed postoperative BC RT were included in this prospective longitudinal cohort study with assessments before RT (baseline) and after 3, 6, and 1

SUBMITTER: Karlsen J 

PROVIDER: S-EPMC12666717 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature