A comparison of institutional review board models and study efficiency in the Environmental influences on Child Health Outcomes Cohort Consortium.

ABSTRACT:

Background

Institutional review board (IRB) approval is a key step in site activation and study initiation. Single IRBs aim to improve the timeliness of IRB review through centralization and standardization, whereas local IRBs conduct reviews only for specific sites. In Cycle 1 of the Environmental influences on Child Health Outcomes (ECHO) Cohort Consortium, 110 sites chose either single or local IRB review, providing the opportunity to compare the efficiency of single versus local IRBs within one multicenter observational study.

Objectives

Data were collected from the ECHO Coordinating Center at the Duke Clinical Research Institute. Primary outcomes included: 1) time from IRB submission to approval and 2) time from regulatory pack receipt to first participant enrollment. S

SUBMITTER: Kohlmann T 

PROVIDER: S-EPMC12666723 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature